Blocks peripheral and central (brain in the trigger zone), dopamine receptors, dopamine eliminates the inhibitory effect on motor function of the gastrointestinal tract testosterone enanthate 250 and enhances evacuation and gastric motility. Has antiemetic effect, soothes hiccup and eliminates nausea.Increasing the concentration of prolactin in the blood serum. Pharmacokinetics. Absorption after oral administration on an empty stomach – fast (reception after eating, decreased gastric acidity slow down and reduce absorption).
- Vomiting and nausea of various origins (including on the background of functional and organic diseases, infections, and toxemia, radiation therapy, diet violations, drug genesis – receiving morphine, apomorphine, levodopa and bromocriptine; during endoscopic and X-ray contrast gastrointestinal studies tract), hiccups, atony of the gastrointestinal tract (including post-operative); the need to accelerate peristalsis during the X-ray contrast studies of the gastrointestinal tract.
- Dyspeptic disorders on the background of slow oprozhneniya stomach, gastroesophageal reflux and esophagitis: a feeling of fullness in the epigastrium, feeling of bloating, flatulence, gastralgia, belching, heartburn with or without regurgitation of gastric contents into the casting mouth.
Hypersensitivity, bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, infancy (up to 5 years of age and for children weighing up to 20 kg).
Renal and / or hepatic testosterone enanthate 250 insufficiency, during lactation, pregnancy.
Pregnancy and lactation
Use of the drug during pregnancy or lactation is allowed, if the expected benefit to the mother outweighs the potential risk to the fetus and child.
Dosing and Administration
Inside for 30 minutes before a meal.
Adults and children over 5 years with chronic dyspeptic phenomena – 10 mg 3-4 times a day and, if necessary, further bedtime. In severe nausea and vomiting – 20 mg 3-4 times a day and at bedtime.
In severe nausea and vomiting – 5 mg / 10 kg 3-4 times a day and at bedtime. Dose could be doubled if necessary. For patients with renal failure dose adjustment is necessary, frequency of intake should not exceed 1-2 times during the day.
Side effect From the digestive system: transient intestinal cramps. Nervous system: extrapyramidal disorder (in children and patients with increased permeability of the blood-brain barrier). Allergic reactions:skin rash, urticaria. Other: hyperprolactinemia (galactorrhea, gynecomastia).
Overdosing Symptoms: drowsiness, disorientation, extrapyramidal disorder (especially in children). Treatment: reception activated carbon, with extrapyramidal disorders -antiholinergicheskie drugs, antihistamines or antiparkinsonian medicinal products with anticholinergic properties.
Interaction with other drugs
cimetidine, sodium bicarbonate reduces the bioavailability of domperidone. Anticholinergic drugs neutralize domperidone.
Increase in plasma concentration of domperidone: antifungal azole drugs, macrolide antibiotics, HIV protease inhibitors, nefazodone (antidepressant). Compatible with antipsychotic drugs (neuroleptics), agonists of dopaminergic receptors (bromocriptine, levodopa).
Simultaneous treatment with paracetamol and digoxin had no effect on the concentration testosterone enanthate 250 of these drugs in the blood.